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BARE by DrB Daily Probiotic

BARE by DrB Daily Probiotic

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 Clinical Applications

Helps Maintain a Healthy Intestinal Microecology* Supports the Natural Immune Response*
Supports Bowel Regularity*
Supports Lactose Digestion*

Daily Probiotic is a vegetarian, dairy- and gluten-free, four-strain probiotic totaling 100 billion CFU† per capsule. Each vegetarian capsule is sealed in nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics such as heat, moisture, and oxygen. Daily Probiotic provides four researched strains of beneficial bacteria, including the extensively studied HN019® strain of Bifidobacterium lactis. These live microorganisms have proven health benefits and well-established safety, and have been tested for epithelial cell adhesion and/or resistance to low pH.*

To further support resistance to low pH and the delivery of microorganisms to the small intestines, Bare by Dr. Bollmann employs DRcapsTM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid and ensure more targeted release.*

All BARE by Dr. Bollmann Formulas Meet or Exceed cGMP Quality Standards

Discussion

Supplementation with probiotics has many mechanisms of action that benefit health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.*[1-8]

Common challenges associated with probiotic supplementation are maintaining stability of the organisms during distribution and shelf life and, once taken by a consumer, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (intestines) alive. To help ensure stability, Bare by Dr. Bollmann packages the Daily Probiotic capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Careful selection of organisms is another way Bare by Dr. Bollmann helps ensure stability. Careful organism selection, as performed for Daily Probiotic, is also a critical aspect of supporting digestive survival. To further support resistance to low pH and the delivery of microorganisms to the small intestines, Bare by Dr. Bollmann employs DRcapsTM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid to promote a more targeted release.*

HOWARUTM (Bifidobacterium lactis HN019®) Discovered in 1899, B lactis play a key role in the human microflora throughout a person’s life. Researchers have identified strain HN019® as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate.[6] B lactis HN019® has been extensively studied, and its safety and effectiveness is well accepted.[7,8] To assess the impact of Bifidobacterium lactis HN019® supplementation on whole-gut transit time in adults, 100 subjects were given daily doses for 14 days of 17.2 billion colony-forming units (CFU), 1.8 billion CFU, or placebo. Decreases in mean whole-gut transit time over the 14-day study period were statistically significant in the high-dose group and the low-dose group, but not in the placebo group.[8] This level of dosing also supported other parameters of healthy GI function, as were self-reported by patient survey.[8] In another study of preschool-age children, supplementing milk for one year with 1.9 x 10 CFU per day B lactis HN019® and 2.4 g/day of prebiotic oligosaccharides supported both healthy iron status and weight gain.[9] In a randomized, double-blind, placebo-controlled human dietary intervention study in elderly subjects (>60 yrs.), supplementary B lactis HN019® resulted in statistically significant increases in the beneficial organisms bifidobacteria and lactobacilli.*[10]

Lactobacillus acidophilus (Lactobacillus acidophilus La-14) This common inhabitant of the human mouth, intestinal tract, and vagina, is also found in some traditional fermented milks (e.g., kefir) and is widely used in probiotic foods and supplements. It has a history of safe human consumption. The L acidophilus La-14 strain is of human origin and has been identified as a type A1 L acidophilus. L acidophilus shows excellent adhesion to human epithelial cell-lines.*[11,12]

Lactobacillus plantarum (Lactobacillus plantarum Lp-115) This bacteria was isolated from plant material and is abundantly present in lactic acid-fermented foods, such as olives and sauerkraut. In vitro studies have shown that L plantarum strain Lp-115 has excellent adhesion to epithelial cell lines.[13] In addition, L plantarum is resistant to low pH conditions and survives the presence of bile at duodenal concentrations.*[13,14]

Bifidobacterium longum (Bifidobacterium longum Bl-05) The B longum Bl-05 strain is well accepted as safe for human consumption. B longum is resistant to low pH and bile salts and is well suited to the intestinal environment.*[14]

Distributed By: BARE by Dr. Bollmann
Scottsdale, AZ 85255
(480) 888-6644
baredrb.com

Daily Probiotic

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Daily Probiotic

Supplement Facts

Serving Size: 1 Capsule Servings Per Container: 30

Amount Per Serving %Daily Value

Proprietary Blend 174 mg (15 Billion CFU) ** Lactobacillus acidophilus La-14S1
Bifidobacterium longum Bl-05S2
Lactobacillus plantarum Lp-115S3

Bifidobacterium lactis 50 mg (15 Billion CFU) ** HN019S4

**Daily Value not established.

Other Ingredients: Microcrystalline cellulose, capsule (hypromellose, gellan gum, and water), stearic acid, magnesium stearate, and silica.

† Colony-Forming Unit

S1. La-14® is a registered trademark of DuPont. S2. Bl-05TM is a trademark of DuPont.
S3. Lp-115
® is a registered trademark of DuPont.

S4. HOWARU® and the HOWARU® logo are registered trademarks of DuPont or its affiliates.
HN019
® is a registered trademark of FonterraTM Limited and is licensed to DuPont Nutrition Biosciences.

References

Directions

Take one capsule with water daily, or as directed by your healthcare professional.

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional.

Formulated To Exclude

Wheat, gluten, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

1. Vanderpool C, Yan F, Polk DB. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Nov;14(11):1585-96. [PMID: 18623173]

2. Abratt VR, Reid SJ. Oxalate-degrading bacteria of the human gut as probiotics in the management of kidney stone disease. Adv Appl Microbiol. 2010;72:63-87. [PMID: 20602988] 3. Masood MI, Qadir MI, Shirazi JH, et al. Beneficial effects of lactic acid bacteria on human beings. Crit Rev Microbiol. 2011 Feb;37(1):91-98. [PMID: 21162695]

4. Turroni S, Vitali B, Bendazzoli C, et al. Oxalate consumption by lactobacilli: evaluation of oxalyl-CoA decarboxylase and formyl-CoA transferase activity in Lactobacillus acidophilus. J Appl Microbiol. 2007 Nov;103(5):1600-09. [PMID: 17953571]

5. Shu Q, Lin H, Rutherfurd KJ, et al. Dietary Bifidobacterium lactis (HN019) enhances resistance to oral Salmonella typhimurium infection in mice. Microbiol Immunol. 2000;44(4):213-22. [PMID: 10832963]

6. Gopal P, et al. Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutr. Res. 2003;23:1313-28. http://www.daniscosupplements.com/clinical-study-bibliography.html. Accessed June 24, 2011.

7. Danisco. Clinical study bibliography & abstracts. HOWARU Bifido – Bif. lactis HN019. http://www.daniscosupplements.com/clinical-study-bibliography.html. Accessed June 24, 2011. 8. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J

Gastroenterol. 2011 Sep;46(9):1057-64. [PMID: 21663486]
9. Sazawal S, Dhingra U, Hiremath G, et al. Effects of
Bifidobacterium lactis HN019 and prebiotic oligosaccharide added to milk on iron status, anemia, and growth among children 1 to 4

years old. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):341-46. [PMID: 20601905]
10. Ahmed M, Prasad J, Gill H, et al. Impact of consumption of different levels of
Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging.

2007 Jan-Feb;11(1):26-31. [ 17315077]

11. Greene JD, Klaenhammer TR. Factors involved in adherence of lactobacilli to human Caco-2 cells. Appl Environ Microbiol. 1994 Dec;60(12):4487-94. [PMID: 7811085]

12. Kleeman EG, Klaenhammer TR. Adherence of Lactobacillus species to human fetal intestinal cells. J Dairy Sci. 1982 Nov;65(11):2063-69. [PMID: 7153393].

13. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007 Oct;45(4):454-60. [PMID: 17897389]

14. Ding WK, Shah NP. Acid, bile, and heat tolerance of free and microencapsulated probiotic bacteria. J Food Sci. 2007 Nov;72(9):M446-50. [PMID: 18034741]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

 

 

Proprietary Blend 445 mg

     Lactobacillus acidophilus, Bifidobacterium lactis

     Lactobacillus casei, Lactobacillus plantarum

     Lactobacillus rhamnosus, Bifidobacterium longum

     Streptococcus thermophilus

Total Probiotic CFU (colony forming units) 100 billion at time of manufacture

Other Ingredients: Tapioca maltodextrin, vegetable capsule (hypromellose and water), FOS (Fructooligosaccharides), vegetable stearate and silicon dioxide

 

     

 

 

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