Dr Bollmann, Skin Care Specialist, Anti-Aging ExpertWe have been aware of the importance of stress in health-related issues. The more stress, the unhealthier the individual. Now studies are showing the importance of stress on stem cells, which are important in cell differentiation.
A stem cell is an unspecialized cell that can give rise to one or more different types of specialized cells, such as blood cells and nerve cells. Stem cells are present in embryos and in various tissues of adult organisms and are widely used in scientific research.
Hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells. The accumulation of DNA damage in HSCs is a hallmark of aging and is a likely major contributing factor in age-related tissue degeneration and cancers.
Michael Milsom, from Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (Germany), and colleagues have observed that the increased energy demands of the stem cells during stress result in elevated production of reactive metabolites that can directly damage DNA.
When this occurs concurrently to the cell’s DNA replication process, the stem cell may die or acquire mutations that may cause cancer.
The team then utilized a mouse model of Fanconi anemia, finding that the stress response causes bone marrow hematopietic stem cells to be severely depleted.
The study authors submit that: “Our findings establish a novel link between physiological stress and DNA damage in normal [hematopoietic stem cells] and provide a mechanistic explanation for the universal accumulation of DNA damage in [hematopoietic stem cells] during ageing and the accelerated failure of the haematopoietic system in Fanconi anaemia patients.”
